| Short Description : | Recombinant-Cynomolgus CTLA-4/CD152-C-His protein was developed in hek293 cells using the region Ala37-Ser160. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Recombinant Cynomolgus CTLA-4/CD152 Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Ala37-Ser160. |
| Immunogen Region: | Ala37-Ser160 |
| Background | CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) , also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. |
Information sourced from Uniprot.org
