Cell Surface Glycoprotein MUC18 Positive Control for STJ501820 peptide (STJ505576)

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STJ505576-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Cell Surface Glycoprotein MUC18 Positive Control for STJ501820 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:2, 500-1:5, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Mcam
Gene ID: 78967
Uniprot ID: MUC18_RAT
Specificity: This is positive control is recommended for use in combination with Cell Surface Glycoprotein MUC18 antibody STJ501820.
Immunogen: Purified Protein
Tissue Specificity Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level).
Function Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Peptide Name Cell Surface Glycoprotein Muc18
Gicerin
Melanoma Cell Adhesion Molecule
Melanoma-Associated Antigen Muc18
Cd Antigen Cd146
Database Links Reactome: R-RNO-8980692
Reactome: -RNO-9013026
Reactome: -RNO-9013149
Reactome: -RNO-9013404
Reactome: -RNO-9013405
Reactome: -RNO-9013408
Reactome: -RNO-9035034
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Perikaryon
Detected At The Surface Of The Cell Body Of Motor Neurons
Alternative Peptide Names Cell Surface Glycoprotein Muc18 protein
Gicerin protein
Melanoma Cell Adhesion Molecule protein
Melanoma-Associated Antigen Muc18 protein
Cd Antigen Cd146 protein
Mcam protein
Muc18 protein

Information sourced from Uniprot.org

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