| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Cell Surface Glycoprotein MUC18 Blocking Peptide for STJ501820 is synthetically produced from the 330-353 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Mcam |
| Gene ID: |
78967 |
| Uniprot ID: |
MUC18_RAT |
| Immunogen Region: |
330-353 |
| Specificity: |
This blocking peptide is recommended for use in combination with Cell Surface Glycoprotein MUC18 antibody, STJ501820 |
| Immunogen: |
Synthetic peptide taken within amino acid region 330-353 on rat Cell Surface Glycoprotein MUC18 protein. |
| Tissue Specificity | Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level). |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Peptide Name | Cell Surface Glycoprotein Muc18GicerinMelanoma Cell Adhesion MoleculeMelanoma-Associated Antigen Muc18Cd Antigen Cd146 |
| Database Links | Reactome: R-RNO-8980692Reactome: -RNO-9013026Reactome: -RNO-9013149Reactome: -RNO-9013404Reactome: -RNO-9013405Reactome: -RNO-9013408Reactome: -RNO-9035034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonDetected At The Surface Of The Cell Body Of Motor Neurons |
| Alternative Peptide Names | Cell Surface Glycoprotein Muc18 proteinGicerin proteinMelanoma Cell Adhesion Molecule proteinMelanoma-Associated Antigen Muc18 proteinCd Antigen Cd146 proteinMcam proteinMuc18 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
