| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CD300 Blocking Peptide is synthetically produced from the 230-290 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
CD300LF |
| Gene ID: |
146722 |
| Uniprot ID: |
CLM1_HUMAN |
| Immunogen Region: |
230-290 |
| Immunogen: |
Synthetic peptide taken within amino acid region 230-290 on human CMRF35-like molecule 1/CD300LF. |
| Tissue Specificity | Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells. |
| Post Translational Modifications | Phosphorylated on tyrosine. |
| Function | Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. |
| Peptide Name | Cmrf35-Like Molecule 1Clm-1Cd300 Antigen-Like Family Member FImmune Receptor Expressed On Myeloid Cells 1Irem-1Immunoglobulin Superfamily Member 13Igsf13Nk Inhibitory ReceptorCd Antigen Cd300f |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Peptide Names | Cmrf35-Like Molecule 1 proteinClm-1 proteinCd300 Antigen-Like Family Member F proteinImmune Receptor Expressed On Myeloid Cells 1 proteinIrem-1 proteinImmunoglobulin Superfamily Member 13 proteinIgsf13 proteinNk Inhibitory Receptor proteinCd Antigen Cd300f proteinCD300LF proteinCD300F proteinCLM1 proteinIGSF13 proteinIREM1 proteinNKIR proteinUNQ3105 proteinPRO10111 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
