| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | CCR6 Blocking Peptide is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | CCR6 |
| Gene ID: | 1235 |
| Uniprot ID: | CCR6_HUMAN |
| Immunogen Region: | 1-50 aa |
| Immunogen: | Synthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 6 protein. |
| Tissue Specificity | Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes. |
| Function | Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells. Positively regulates sperm motility and chemotaxis via its binding to CCL20. |
| Peptide Name | C-C Chemokine Receptor Type 6 C-C Ckr-6 Cc-Ckr-6 Ccr-6 Chemokine Receptor-Like 3 Ckr-L3 Dry6 G-Protein Coupled Receptor 29 Gpr-Cy4 Gprcy4 Larc Receptor Cd Antigen Cd196 |
| Database Links | Reactome: R-HSA-1461957 Reactome: R-HSA-380108 Reactome: R-HSA-418594 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Surface |
| Alternative Peptide Names | C-C Chemokine Receptor Type 6 protein C-C Ckr-6 protein Cc-Ckr-6 protein Ccr-6 protein Chemokine Receptor-Like 3 protein Ckr-L3 protein Dry6 protein G-Protein Coupled Receptor 29 protein Gpr-Cy4 protein Gprcy4 protein Larc Receptor protein Cd Antigen Cd196 protein CCR6 protein CKRL3 protein CMKBR6 protein GPR29 protein STRL22 protein |
Information sourced from Uniprot.org