| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CC2D1A Positive Control for STJ500383 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
CC2D1A |
| Gene ID: |
54862 |
| Uniprot ID: |
C2D1A_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with CC2D1A antibody STJ500383. |
| Immunogen: |
Purfied protein. |
| Post Translational Modifications | Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21. |
| Function | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. |
| Peptide Name | Coiled-Coil And C2 Domain-Containing Protein 1aAkt Kinase-Interacting Protein 1Five Prime Repressor Element Under Dual Repression-Binding Protein 1Fre Under Dual Repression-Binding Protein 1Freud-1Putative Nf-Kappa-B-Activating Protein 023n |
| Cellular Localisation | CytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Peptide Names | Coiled-Coil And C2 Domain-Containing Protein 1a proteinAkt Kinase-Interacting Protein 1 proteinFive Prime Repressor Element Under Dual Repression-Binding Protein 1 proteinFre Under Dual Repression-Binding Protein 1 proteinFreud-1 proteinPutative Nf-Kappa-B-Activating Protein 023n proteinCC2D1A proteinAKI1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
