| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | CaMKII gamma Blocking Peptide is synthetically produced from the 400-455 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | CAMK2G |
| Gene ID: | 818 |
| Uniprot ID: | KCC2G_HUMAN |
| Immunogen Region: | 400-455 |
| Immunogen: | Synthetic peptide taken within amino acid region 400-455 on human CAMKII gamma protein. |
| Tissue Specificity | Expressed in skeletal muscle. |
| Post Translational Modifications | Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. |
| Peptide Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Gamma Cam Kinase Ii Subunit Gamma Camk-Ii Subunit Gamma |
| Database Links | Reactome: R-HSA-111932 Reactome: R-HSA-3371571 Reactome: R-HSA-399719 Reactome: R-HSA-438066 Reactome: R-HSA-442729 Reactome: R-HSA-442982 Reactome: R-HSA-5576892 Reactome: R-HSA-5578775 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-6802946 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-877300 Reactome: R-HSA-9022692 Reactome: R-HSA-936837 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 |
| Cellular Localisation | Sarcoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side |
| Alternative Peptide Names | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Gamma protein Cam Kinase Ii Subunit Gamma protein Camk-Ii Subunit Gamma protein CAMK2G protein CAMK protein CAMK-II protein CAMKG protein |
Information sourced from Uniprot.org