Calcium Sensing Receptor Positive Control peptide (STJ503814)

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STJ503814-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Calcium Sensing Receptor Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CASR
Gene ID: 846
Uniprot ID: CASR_HUMAN
Tissue Specificity Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
Post Translational Modifications N-glycosylated. Ubiquitinated by RNF19A.which induces proteasomal degradation.
Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
Peptide Name Extracellular Calcium-Sensing Receptor
Car
Casr
Hcasr
Parathyroid Cell Calcium-Sensing Receptor 1
Pcar1
Database Links Reactome: R-HSA-416476
Reactome: R-HSA-418594
Reactome: R-HSA-420499
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Extracellular Calcium-Sensing Receptor protein
Car protein
Casr protein
Hcasr protein
Parathyroid Cell Calcium-Sensing Receptor 1 protein
Pcar1 protein
CASR protein
GPRC2A protein
PCAR1 protein

Information sourced from Uniprot.org

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