BMP11 Blocking Peptide peptide (STJ503730)

Name: BMP11 Blocking Peptide peptide (STJ503730)
SKU: STJ503730-250
Price: 260.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ImmunogenSynthetic peptide taken within amino acid region 60-100 on human BMP11/GDF11 protein.

STJ503730-250

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Short Description	BMP11 Blocking Peptide is synthetically produced from the 60-100 sequence and is suitable for use in western blot applications.
Applications	Immunodepletion/Immunocompetition
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	GDF11
Gene ID	10220
Uniprot ID	GDF11_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 60-100 on human BMP11/GDF11 protein.
Immunogen Region	60-100

Tissue Specificity	In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme.
Post Translational Modifications	Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases. This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.
Function	Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.
Peptide Name	Growth/Differentiation Factor 11 Gdf-11 Bone Morphogenetic Protein 11 Bmp-11
Cellular Localisation	Secreted
Alternative Peptide Names	Growth/Differentiation Factor 11 protein Gdf-11 protein Bone Morphogenetic Protein 11 protein Bmp-11 protein GDF11 protein BMP11 protein

Information sourced from Uniprot.org