Bestrophin Blocking Peptide peptide (STJ503718)
SPECIFICATIONS
ImmunogenMid-Region Synthetic peptide corresponding to unique amino acid sequences on human Bestrophin 1 protein.
General Information
| Short Description | Bestrophin Blocking Peptide is synthetically produced from the Mid-region sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | BEST1 |
| Gene ID | 7439 |
| Uniprot ID | BEST1_HUMAN |
| Immunogen | Mid-Region Synthetic peptide corresponding to unique amino acid sequences on human Bestrophin 1 protein. |
| Immunogen Region | Mid-region |
Additional Info
| Tissue Specificity | Predominantly expressed in the basolateral membrane of the retinal pigment epithelium. |
| Function | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+). Allows the movement of chloride and hydrogencarbonate. Found in a partially open conformation leading to significantly smaller chloride movement. Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation. Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition. Releases the 4-aminobutanoate neurotransmitter in a (Ca2+)-dependent manner, and participates in its tonic release from cerebellar glial cells. |
| Peptide Name | Bestrophin-1Tu15bVitelliform Macular Dystrophy Protein 2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocalized At The Surface Membrane Of Microdomains Adjacent To Glutamatergic Synapses |
| Alternative Peptide Names | Bestrophin-1 proteinTu15b proteinVitelliform Macular Dystrophy Protein 2 proteinBEST1 proteinVMD2 protein |
Information sourced from Uniprot.org