Tissue Specificity | Isoform 1: Expressed in heart. Isoform 2: Expressed in brain, retina/retinal pigment epithelium (RPE) and skeletal muscle. Expressed in acinar cells of parotid glands. Expressed in lung, kidney and testis. |
Function | Isoform 1: Ligand-gated anion channel that allows the movement of chloride monoatomic anions across cell membranes when activated by calcium (Ca2+). Isoform 2: Does not function as calcium-gated chloride channel. |
Peptide Name | Bestrophin-3Vitelliform Macular Dystrophy 2-Like Protein 3 |
Database Links | Reactome: R-MMU-2672351 |
Cellular Localisation | Isoform 1: Cell MembraneLocalized Also In Punctate Structures In The Cytosolic CompartmentIsoform 2: Cell Membrane |
Alternative Peptide Names | Bestrophin-3 proteinVitelliform Macular Dystrophy 2-Like Protein 3 proteinBest3 proteinVmd2l3 protein |
Information sourced from Uniprot.org