| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Bestrophin 2 Blocking Peptide is synthetically produced from the 388-404 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Best2 |
| Gene ID: |
212989 |
| Uniprot ID: |
BEST2_MOUSE |
| Immunogen Region: |
388-404 |
| Immunogen: |
Synthetic peptide taken within amino acid region 388-404 of mouse Bestrophin 2 protein, peptide was covalently modified. Sequence: EVHGDFLQRLLPAGAGS |
| Tissue Specificity | Expressed in mucin-secreting colonic goblet cells. |
| Function | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide. Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture. Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion. In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate.binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans. Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate. |
| Peptide Name | Bestrophin-2Vitelliform Macular Dystrophy 2-Like Protein 1 |
| Database Links | Reactome: R-MMU-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Peptide Names | Bestrophin-2 proteinVitelliform Macular Dystrophy 2-Like Protein 1 proteinBest2 proteinVmd2l1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
