| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
BACE2 B Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Tissue Specificity | Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. |
| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Peptide Name | Beta-Secretase 2Aspartic-Like Protease 56 KdaAspartyl Protease 1Asp1Asp 1Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2Beta-Site App Cleaving Enzyme 2Down Region Aspartic ProteaseDrapMemapsin-1Membrane-Associated Aspartic Protease 1Theta-Secretase |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusEndoplasmic ReticulumEndosomeMelanosomeColocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Peptide Names | Beta-Secretase 2 proteinAspartic-Like Protease 56 Kda proteinAspartyl Protease 1 proteinAsp1 proteinAsp 1 proteinBeta-Site Amyloid Precursor Protein Cleaving Enzyme 2 proteinBeta-Site App Cleaving Enzyme 2 proteinDown Region Aspartic Protease proteinDrap proteinMemapsin-1 proteinMembrane-Associated Aspartic Protease 1 proteinTheta-Secretase proteinBACE2 proteinAEPLC proteinALP56 proteinASP21 proteinCDA13 proteinUNQ418 proteinPRO852 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
