BACE2 A/C Blocking Peptide peptide (STJ503692)

SKU:
STJ503692-250

£289.50
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: BACE2 A/C Blocking Peptide is synthetically produced from the 490-518 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: BACE2
Gene ID: 25825
Uniprot ID: BACE2_HUMAN
Immunogen Region: 490-518
Immunogen: Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.
Tissue Specificity Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Post Translational Modifications Undergoes autoproteolytic cleavage. Glycosylated.
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Peptide Name Beta-Secretase 2
Aspartic-Like Protease 56 Kda
Aspartyl Protease 1
Asp1
Asp 1
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2
Beta-Site App Cleaving Enzyme 2
Down Region Aspartic Protease
Drap
Memapsin-1
Membrane-Associated Aspartic Protease 1
Theta-Secretase
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Endoplasmic Reticulum
Endosome
Melanosome
Colocalizes With Pmel In Stage I And Ii Melanosomes
Alternative Peptide Names Beta-Secretase 2 protein
Aspartic-Like Protease 56 Kda protein
Aspartyl Protease 1 protein
Asp1 protein
Asp 1 protein
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 protein
Beta-Site App Cleaving Enzyme 2 protein
Down Region Aspartic Protease protein
Drap protein
Memapsin-1 protein
Membrane-Associated Aspartic Protease 1 protein
Theta-Secretase protein
BACE2 protein
AEPLC protein
ALP56 protein
ASP21 protein
CDA13 protein
UNQ418 protein
PRO852 protein

Information sourced from Uniprot.org

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