| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Aquaporin 9 Blocking Peptide is synthetically produced from the 250-294 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Aqp9 |
| Gene ID: |
65054 |
| Uniprot ID: |
AQP9_RAT |
| Immunogen Region: |
250-294 |
| Immunogen: |
Synthetic peptide taken within amino acid region 250-294 on rat Aquaporin 9 protein. |
| Tissue Specificity | Detected in testis and liver. Detected in immature spermatocytes and in interstitial Leydig cells. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis. It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium. |
| Peptide Name | Aquaporin-9Aqp-9Aquaglyceroporin-9 |
| Database Links | Reactome: R-RNO-432030Reactome: -RNO-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneFunctions At The Hepatocyte Basolateral Membrane |
| Alternative Peptide Names | Aquaporin-9 proteinAqp-9 proteinAquaglyceroporin-9 proteinAqp9 proteinAqp9l protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
