| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Aquaporin 11 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Tissue Specificity | Expressed in retina specifically at retinal Mueller glial cells. Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells. |
| Post Translational Modifications | Not glycosylated. |
| Function | Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development. |
| Peptide Name | Aquaporin-11Aqp-11 |
| Database Links | Reactome: R-RNO-432047 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell MembraneCytoplasmPerinuclear RegionLocalizes Mainly To The Periphery Of Lipid DropletsIt Accumulates Partly In Mitochondrial-Associated Endoplasmic Reticulum Membranes |
| Alternative Peptide Names | Aquaporin-11 proteinAqp-11 proteinAqp11 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
