| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Aph 1b Blocking Peptide is synthetically produced from the 235-257 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | APH1B |
| Gene ID: | 83464 |
| Uniprot ID: | APH1B_HUMAN |
| Immunogen Region: | 235-257 |
| Immunogen: | Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein. |
| Tissue Specificity | Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. |
| Function | Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. |
| Peptide Name | Gamma-Secretase Subunit Aph-1bAph-1bAph-1betaPresenilin-Stabilization Factor-Like |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-193692Reactome: R-HSA-205043Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-3928665Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9017802Reactome: R-HSA-977225Reactome: R-HSA-9839383 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Gamma-Secretase Subunit Aph-1b proteinAph-1b proteinAph-1beta proteinPresenilin-Stabilization Factor-Like proteinAPH1B proteinPSFL proteinUNQ688 proteinPRO1328 protein |
Information sourced from Uniprot.org