| Post Translational Modifications | (Microbial infection) Methylation at Cys-630 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts ability to bind 'Lys-63'-linked ubiquitin. |
| Function | DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. |
| Protein Name | Dna Annealing Helicase And Endonuclease Zranb3Annealing Helicase 2Ah2Zinc Finger Ran-Binding Domain-Containing Protein 3 Includes - Dna Annealing Helicase Zranb3 - Endonuclease Zranb3 |
| Cellular Localisation | NucleusChromosomeFollowing Dna DamageRecruited To Sites Of Dna Damage And Stalled Replication Forks By Polyubiquitinated Pcna |
| Alternative Antibody Names | Anti-Dna Annealing Helicase And Endonuclease Zranb3 antibodyAnti-Annealing Helicase 2 antibodyAnti-Ah2 antibodyAnti-Zinc Finger Ran-Binding Domain-Containing Protein 3 Includes - Dna Annealing Helicase Zranb3 - Endonuclease Zranb3 antibodyAnti-ZRANB3 antibody |
Information sourced from Uniprot.org
