Anti-ZNRF2 antibody [R09-5G1] (STJA0036234)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human ZNRF2
General Information
| Short Description | Rabbit monoclonal anti-ZNRF2 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-5G1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ZNRF2 |
| Gene ID | 223082 |
| Uniprot ID | ZNRF2_HUMAN |
| Immunogen | A synthesized peptide derived from human ZNRF2 |
Additional Info
| Tissue Specificity | Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. |
| Post Translational Modifications | Phosphorylated.leading to binding to YWHAE. Phosphorylated by MTOR at Ser-145 and dephosphorylated by PP6C. Ser-145 phosphorylation stimulates vesicle-to-cytosol translocation. |
| Function | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism. |
| Protein Name | E3 Ubiquitin-Protein Ligase Znrf2Protein Ells2Ring Finger Protein 202Ring-Type E3 Ubiquitin Transferase Znrf2Zinc/Ring Finger Protein 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLysosome MembranePresynaptic Cell MembraneCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Znrf2 antibodyAnti-Protein Ells2 antibodyAnti-Ring Finger Protein 202 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Znrf2 antibodyAnti-Zinc/Ring Finger Protein 2 antibodyAnti-ZNRF2 antibodyAnti-RNF202 antibody |
Information sourced from Uniprot.org