| Tissue Specificity | Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. |
| Post Translational Modifications | Phosphorylated.leading to binding to YWHAE. Phosphorylated by MTOR at Ser-145 and dephosphorylated by PP6C. Ser-145 phosphorylation stimulates vesicle-to-cytosol translocation. |
| Function | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism. |
| Protein Name | E3 Ubiquitin-Protein Ligase Znrf2Protein Ells2Ring Finger Protein 202Ring-Type E3 Ubiquitin Transferase Znrf2Zinc/Ring Finger Protein 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLysosome MembranePresynaptic Cell MembraneCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Znrf2 antibodyAnti-Protein Ells2 antibodyAnti-Ring Finger Protein 202 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Znrf2 antibodyAnti-Zinc/Ring Finger Protein 2 antibodyAnti-ZNRF2 antibodyAnti-RNF202 antibody |
Information sourced from Uniprot.org
