Anti-ZNRF2 antibody (Internal Region) (STJA0005780)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids from an internal region of human DPP10 protein
General Information
| Short Description | Rabbit polyclonal anti-ZNRF2 (Internal Region) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | PBS + 0.02% NaN3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNRF2 |
| Gene ID | 223082 |
| Uniprot ID | ZNRF2_HUMAN |
| Immunogen | Synthetic peptide corresponding to amino acids from an internal region of human DPP10 protein |
| Immunogen Region | Internal Region |
| Specificity | Reacts with an internal region of the 24 kDa human ZNRF2 protein. 87% sequence identity to rat and 81% sequence identity to mouse. |
Additional Info
| Post Translational Modifications | Phosphorylated.leading to binding to YWHAE. Phosphorylated by MTOR at Ser-145 and dephosphorylated by PP6C. Ser-145 phosphorylation stimulates vesicle-to-cytosol translocation. |
| Function | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism. |
| Protein Name | E3 Ubiquitin-Protein Ligase Znrf2Protein Ells2Ring Finger Protein 202Ring-Type E3 Ubiquitin Transferase Znrf2Zinc/Ring Finger Protein 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLysosome MembranePresynaptic Cell MembraneCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Znrf2 antibodyAnti-Protein Ells2 antibodyAnti-Ring Finger Protein 202 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Znrf2 antibodyAnti-Zinc/Ring Finger Protein 2 antibodyAnti-ZNRF2 antibodyAnti-RNF202 antibody |
Information sourced from Uniprot.org