| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZNRF2 (Internal Region) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNRF2 |
| Gene ID: |
223082 |
| Uniprot ID: |
ZNRF2_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Reacts with an internal region of the 24 kDa human ZNRF2 protein. 87% sequence identity to rat and 81% sequence identity to mouse. |
| Immunogen: |
Synthetic peptide corresponding to amino acids from an internal region of human DPP10 protein |
| Post Translational Modifications | Phosphorylated.leading to binding to YWHAE. Phosphorylated by MTOR at Ser-145 and dephosphorylated by PP6C. Ser-145 phosphorylation stimulates vesicle-to-cytosol translocation. |
| Function | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism. |
| Protein Name | E3 Ubiquitin-Protein Ligase Znrf2Protein Ells2Ring Finger Protein 202Ring-Type E3 Ubiquitin Transferase Znrf2Zinc/Ring Finger Protein 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLysosome MembranePresynaptic Cell MembraneCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Znrf2 antibodyAnti-Protein Ells2 antibodyAnti-Ring Finger Protein 202 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Znrf2 antibodyAnti-Zinc/Ring Finger Protein 2 antibodyAnti-ZNRF2 antibodyAnti-RNF202 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
