| Short Description : | Rabbit polyclonal Zfp541 (1-1363) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Znf541 |
| Gene ID: | 666528 |
| Uniprot ID: | ZN541_MOUSE |
| Immunogen Region: | 1-1363 |
| Immunogen Sequence: | MEPYSLGEEGALPSEGHLPS FSESQVLNCSDTLNRDLGPS TRDLLYAGLSGLDLDPSLST SDMPSEVLEDNLDTLSLYSG KDSDSVKLLEEYADSESQTS LQDLGLGALKVPKEADEGGR ATGSTRKGKRQHSSPQNPLL DCSLCGKVFSSASSLSKHYL THSQERKHVCKVCSKAFKRQ DHLTGHMLTHQKTKPFVCIE QGCSKSYCDYRSLRRHYEVQ HGVCILKETPPEEEAYGDP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of mouse Zfp541 (NP_001092747.1). |
| Tissue Specificity | Germ-cell-specific. Specifically present in testicular spermatogenic cells, but not in testicular and mature sperm. During spermatogenesis, it is present in spermatocytes and round spermatids only (at protein level). |
| Function | Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis and post-meiosis during spermatogenesis. Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression. |
| Protein Name | Zinc Finger Protein 541Spermatogenic Cell Hdac-Interacting Protein 1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 541 antibodyAnti-Spermatogenic Cell Hdac-Interacting Protein 1 antibodyAnti-Znf541 antibodyAnti-Ship1 antibodyAnti-Zfp541 antibody |
Information sourced from Uniprot.org
