Tissue Specificity | Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins. |
Function | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage.this interaction preventing EBF1 to bind DNA and activate target genes. |
Protein Name | Zinc Finger Protein 521Early Hematopoietic Zinc Finger ProteinLyst-Interacting Protein 3 |
Database Links | Reactome: R-HSA-8940973Reactome: R-HSA-9823739Reactome: R-HSA-9832991 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Zinc Finger Protein 521 antibodyAnti-Early Hematopoietic Zinc Finger Protein antibodyAnti-Lyst-Interacting Protein 3 antibodyAnti-ZNF521 antibodyAnti-EHZF antibodyAnti-LIP3 antibody |
Information sourced from Uniprot.org