| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZNF521 (210-420) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNF521 |
| Gene ID: |
25925 |
| Uniprot ID: |
ZN521_HUMAN |
| Immunogen Region: |
210-420 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-420 of human ZNF521 (NP_056276.1). |
| Immunogen Sequence: |
GFLSSSSLHGHMQVHERNKD GSQSGSRMEDWKMKDTQKCS QCEEGFDFPEDLQKHIAECH PECSPNEDRAALQCVYCHEL FVEETSLMNHMEQVHSGEKK NSCSICSESFHTVEELYSHM DSHQQPESCNHSNSPSLVTV GYTSVSSTTPDSNLSVDSST MVEAAPPIPKSRGRKRAAQQ TPDMTGPSSKQAKVTYSCIY CNKQLFSSLAV |
| Tissue Specificity | Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins. |
| Function | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage.this interaction preventing EBF1 to bind DNA and activate target genes. |
| Protein Name | Zinc Finger Protein 521Early Hematopoietic Zinc Finger ProteinLyst-Interacting Protein 3 |
| Database Links | Reactome: R-HSA-8940973 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 521 antibodyAnti-Early Hematopoietic Zinc Finger Protein antibodyAnti-Lyst-Interacting Protein 3 antibodyAnti-ZNF521 antibodyAnti-EHZF antibodyAnti-LIP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
