Anti-ZNF410 antibody (113-163 aa) (STJ197531)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZN410 at the amino acid range 113-163
General Information
| Short Description | Rabbit polyclonal anti-Zinc finger protein 410 (113-163 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF410 |
| Gene ID | 57862 |
| Uniprot ID | ZN410_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZN410 at the amino acid range 113-163 |
| Immunogen Region | 113-163 aa |
| Specificity | This antibody detects endogenous levels of human ZN410 |
Additional Info
| Post Translational Modifications | Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation. O-glycosylated. O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity. |
| Function | Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4. |
| Protein Name | Zinc Finger Protein 410Another Partner For Arf 1 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeDirectly Binds To The Sequence Motif 5'-Catcccataata-3' |
| Alternative Antibody Names | Anti-Zinc Finger Protein 410 antibodyAnti-Another Partner For Arf 1 antibodyAnti-ZNF410 antibodyAnti-APA1 antibody |
Information sourced from Uniprot.org