| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Zinc finger protein 410 (113-163 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNF410 |
| Gene ID: |
57862 |
| Uniprot ID: |
ZN410_HUMAN |
| Immunogen Region: |
113-163 aa |
| Specificity: |
This antibody detects endogenous levels of human ZN410 |
| Immunogen: |
Synthesized peptide derived from the human ZN410 at the amino acid range 113-163 |
| Post Translational Modifications | Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation. O-glycosylated. O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity. |
| Function | Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4. |
| Protein Name | Zinc Finger Protein 410Another Partner For Arf 1 |
| Cellular Localisation | NucleusChromosomeDirectly Binds To The Sequence Motif 5'-Catcccataata-3' |
| Alternative Antibody Names | Anti-Zinc Finger Protein 410 antibodyAnti-Another Partner For Arf 1 antibodyAnti-ZNF410 antibodyAnti-APA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
