Anti-ZGPAT antibody [C185] (STJA0021783)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Zinc Finger Ccch-Type With G Patch Domain-Containing Protein antibody for use in ELISA, IF and IP in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/IF/IP |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | C185 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | ZGPAT |
| Gene ID | 84619 |
| Uniprot ID | ZGPAT_HUMAN |
Additional Info
| Post Translational Modifications | Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP. |
| Function | Transcription repressor that specifically binds the 5'-GGAGGAAGAA-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. |
| Protein Name | Zinc Finger Ccch-Type With G Patch Domain-Containing ProteinG Patch Domain-Containing Protein 6Zinc Finger Ccch Domain-Containing Protein 9Zinc Finger And G Patch Domain-Containing Protein |
| Database Links | |
| Cellular Localisation | NucleusIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Ccch-Type With G Patch Domain-Containing Protein antibodyAnti-G Patch Domain-Containing Protein 6 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 9 antibodyAnti-Zinc Finger And G Patch Domain-Containing Protein antibodyAnti-ZGPAT antibodyAnti-GPATC6 antibodyAnti-GPATCH6 antibodyAnti-KIAA1847 antibodyAnti-ZC3H9 antibodyAnti-ZC3HDC9 antibodyAnti-ZIP antibody |
Information sourced from Uniprot.org