Anti-ZGPAT antibody (34-84) (STJA0006422)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ZGPAT AA range: 34-84
General Information
| Short Description | Rabbit polyclonal anti-Zinc finger CCCH-type with G patch domain-containing protein (34-84) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZGPAT |
| Gene ID | 84619 |
| Uniprot ID | ZGPAT_HUMAN |
| Immunogen | Synthesized peptide derived from human ZGPAT AA range: 34-84 |
| Immunogen Region | 34-84 |
| Specificity | This antibody detects endogenous levels of human ZGPAT |
Additional Info
| Post Translational Modifications | Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP. |
| Function | Transcription repressor that specifically binds the 5'-GGAGGAAGAA-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. |
| Protein Name | Zinc Finger Ccch-Type With G Patch Domain-Containing ProteinG Patch Domain-Containing Protein 6Zinc Finger Ccch Domain-Containing Protein 9Zinc Finger And G Patch Domain-Containing Protein |
| Database Links | |
| Cellular Localisation | NucleusIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Ccch-Type With G Patch Domain-Containing Protein antibodyAnti-G Patch Domain-Containing Protein 6 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 9 antibodyAnti-Zinc Finger And G Patch Domain-Containing Protein antibodyAnti-ZGPAT antibodyAnti-GPATC6 antibodyAnti-GPATCH6 antibodyAnti-KIAA1847 antibodyAnti-ZC3H9 antibodyAnti-ZC3HDC9 antibodyAnti-ZIP antibody |
Information sourced from Uniprot.org