| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ZFHX3 |
| Gene ID: |
463 |
| Uniprot ID: |
ZFHX3_HUMAN |
| Immunogen Region: |
1470-1750 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1470-1750 of human ZFHX3 (NP_008816.3). |
| Immunogen Sequence: |
NGDLLAMGDPTLAEDHTIIV EEDKEEESDLEDKQSPTGSD SGSVQEDSGSEPKRALPFRK GPNFTMEKFLDPSRPYKCTV CKESFTQKNILLVHYNSVSH LHKLKRALQESATGQPEPTS SPDNKPFKCNTCNVAYSQSS TLEIHMRSVLHQTKARAAKL EAASGSSNGTGNSSSISLSS STPSPVSTSGSNTFTTSNPS SAGIAPSSNLLSQVPTESVG MPPLGNPIGANIASPSEPK |
| Tissue Specificity | Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Expression is higher in ER-positive breast tumors than ER-negative breast tumors (at protein level). |
| Post Translational Modifications | Hyperphosphorylation protects ZFHX3 from calpain/CAPN1-mediated degradation. Ubiquitinated, leading to its proteasomal degradation. Nuclear localization is essential for its sumoylation. |
| Function | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3. Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation. Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells. |
| Protein Name | Zinc Finger Homeobox Protein 3At Motif-Binding Factor 1At-Binding Transcription Factor 1Alpha-Fetoprotein Enhancer-Binding ProteinZinc Finger Homeodomain Protein 3Zfh-3 |
| Database Links | Reactome: R-HSA-8941855 |
| Cellular Localisation | NucleusCytoplasmTranslocates From The Cytoplasm To The Nucleus Following Tgf-Beta StimulationExpressed In Nuclear Body (Nb)-Like Dots In The Nucleus Some Of Which Overlap Or Closely Associate With Pml Body |
| Alternative Antibody Names | Anti-Zinc Finger Homeobox Protein 3 antibodyAnti-At Motif-Binding Factor 1 antibodyAnti-At-Binding Transcription Factor 1 antibodyAnti-Alpha-Fetoprotein Enhancer-Binding Protein antibodyAnti-Zinc Finger Homeodomain Protein 3 antibodyAnti-Zfh-3 antibodyAnti-ZFHX3 antibodyAnti-ATBF1 antibodyAnti-C16orf47 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
