| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Palmitoyltransferase ZDHHC9 (315-364 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZDHHC9 |
| Gene ID: | 51114 |
| Uniprot ID: | ZDHC9_HUMAN |
| Immunogen Region: | 315-364 aa |
| Specificity: | DHHC-9 Polyclonal Antibody detects endogenous levels of DHHC-9 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ZDHHC9 at the amino acid range 315-364 |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD. (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Protein Name | Palmitoyltransferase Zdhhc9 Zinc Finger Dhhc Domain-Containing Protein 9 Dhhc-9 Dhhc9 Zinc Finger Protein 379 Zinc Finger Protein 380 |
| Database Links | Reactome: R-HSA-9648002 Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Golgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc9 antibody Anti-Zinc Finger Dhhc Domain-Containing Protein 9 antibody Anti-Dhhc-9 antibody Anti-Dhhc9 antibody Anti-Zinc Finger Protein 379 antibody Anti-Zinc Finger Protein 380 antibody Anti-ZDHHC9 antibody Anti-CXorf11 antibody Anti-ZDHHC10 antibody Anti-ZNF379 antibody Anti-ZNF380 antibody Anti-CGI-89 antibody Anti-UNQ261 antibody Anti-PRO298 antibody |
Information sourced from Uniprot.org