| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZDHHC9 (250-364) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZDHHC9 |
| Gene ID: |
51114 |
| Uniprot ID: |
ZDHC9_HUMAN |
| Immunogen Region: |
250-364 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 250-364 of human ZDHHC9 (NP_057116.2). |
| Immunogen Sequence: |
VALNQTTNEDIKGSWTGKNR VQNPYSHGNIVKNCCEVLCG PLPPSVLDRRGILPLEESGS RPPSTQETSSSLLPQSPAPT EHLNSNEMPEDSSTPEEMPP PEPPEPPQEAAEAEK |
| Tissue Specificity | Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes. |
| Function | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (Probable). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Protein Name | Palmitoyltransferase Zdhhc9Zinc Finger Dhhc Domain-Containing Protein 9Dhhc-9Dhhc9Zinc Finger Protein 379Zinc Finger Protein 380 |
| Database Links | Reactome: R-HSA-9648002Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc9 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 9 antibodyAnti-Dhhc-9 antibodyAnti-Dhhc9 antibodyAnti-Zinc Finger Protein 379 antibodyAnti-Zinc Finger Protein 380 antibodyAnti-ZDHHC9 antibodyAnti-CXorf11 antibodyAnti-ZDHHC10 antibodyAnti-ZNF379 antibodyAnti-ZNF380 antibodyAnti-CGI-89 antibodyAnti-UNQ261 antibodyAnti-PRO298 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
