| Tissue Specificity | Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes. |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD. (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Protein Name | Palmitoyltransferase Zdhhc9Zinc Finger Dhhc Domain-Containing Protein 9Dhhc-9Dhhc9Zinc Finger Protein 379Zinc Finger Protein 380 |
| Database Links | Reactome: R-HSA-9648002Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc9 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 9 antibodyAnti-Dhhc-9 antibodyAnti-Dhhc9 antibodyAnti-Zinc Finger Protein 379 antibodyAnti-Zinc Finger Protein 380 antibodyAnti-ZDHHC9 antibodyAnti-CXorf11 antibodyAnti-ZDHHC10 antibodyAnti-ZNF379 antibodyAnti-ZNF380 antibodyAnti-CGI-89 antibodyAnti-UNQ261 antibodyAnti-PRO298 antibody |
Information sourced from Uniprot.org
