Anti-ZDHHC8 antibody (289-339 aa) (STJ193770)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZDHC8 at the amino acid range 289-339
General Information
| Short Description | Rabbit polyclonal anti-Palmitoyltransferase ZDHHC8 (289-339 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC8 |
| Gene ID | 29801 |
| Uniprot ID | ZDHC8_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZDHC8 at the amino acid range 289-339 |
| Immunogen Region | 289-339 aa |
| Specificity | This antibody detects endogenous levels of ZDHC8 at Human/Mouse |
Additional Info
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission. (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Protein Name | Palmitoyltransferase Zdhhc8Zinc Finger Dhhc Domain-Containing Protein 8Dhhc-8Zinc Finger Protein 378 |
| Database Links | Reactome: R-HSA-8963896Reactome: R-HSA-9694548 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinMitochondrion Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc8 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 8 antibodyAnti-Dhhc-8 antibodyAnti-Zinc Finger Protein 378 antibodyAnti-ZDHHC8 antibodyAnti-KIAA1292 antibodyAnti-ZDHHCL1 antibodyAnti-ZNF378 antibody |
Information sourced from Uniprot.org