Anti-ZDHHC8 antibody (240-380) (STJ119474)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZDHHC8 (240-380) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC8 |
| Gene ID | 29801 |
| Uniprot ID | ZDHC8_HUMAN |
| Immunogen Region | 240-380 |
| Immunogen Sequence | VEHVLCSPLAPRYVVEPPRL PLAVSLKPPFLRPELLDRAA PLKVKLSDNGLKAGLGRSKS KGSLDRLDEKPLDLGPPLPP KIEAGTFSSDLQTPRPGSAE SALSVQRTSPPTPAMYKFRP AFPTGPKVPFCGPGEQVPGP D |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ZDHHC8 (NP_037505.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission. (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Protein Name | Palmitoyltransferase Zdhhc8Zinc Finger Dhhc Domain-Containing Protein 8Dhhc-8Zinc Finger Protein 378 |
| Database Links | Reactome: R-HSA-8963896Reactome: R-HSA-9694548 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinMitochondrion Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc8 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 8 antibodyAnti-Dhhc-8 antibodyAnti-Zinc Finger Protein 378 antibodyAnti-ZDHHC8 antibodyAnti-KIAA1292 antibodyAnti-ZDHHCL1 antibodyAnti-ZNF378 antibody |
Information sourced from Uniprot.org