Anti-ZDHHC2 antibody (270-367) (STJ119957)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZDHHC2 (270-367) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC2 |
| Gene ID | 51201 |
| Uniprot ID | ZDHC2_HUMAN |
| Immunogen Region | 270-367 |
| Immunogen Sequence | QVFGDEKKYWLLPIFSSLGD GCSFPTCLVNQDPEQASTPA GLNSTAKNLENHQFPAKPLR ESQSHLLTDSQSWTESSINP GKCKAGMSNPALTMENET |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 270-367 of human ZDHHC2 (NP_057437.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis. |
| Post Translational Modifications | Autopalmitoylated. |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses. In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors. Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons. Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane. (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. |
| Protein Name | Palmitoyltransferase Zdhhc2Acyltransferase Zdhhc2Reduced Expression Associated With Metastasis ProteinReamReduced Expression In Cancer ProteinRecZinc Finger Dhhc Domain-Containing Protein 2Dhhc-2Zinc Finger Protein 372 |
| Database Links | Reactome: R-HSA-5683826Reactome: R-HSA-9694548 |
| Cellular Localisation | Postsynaptic DensityPostsynaptic Recycling Endosome MembraneMulti-Pass Membrane ProteinCell MembraneEndoplasmic Reticulum MembraneGolgi Apparatus MembraneTranslocates To Postsynaptic Density When Synaptic Activity Decreases |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc2 antibodyAnti-Acyltransferase Zdhhc2 antibodyAnti-Reduced Expression Associated With Metastasis Protein antibodyAnti-Ream antibodyAnti-Reduced Expression In Cancer Protein antibodyAnti-Rec antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 2 antibodyAnti-Dhhc-2 antibodyAnti-Zinc Finger Protein 372 antibodyAnti-ZDHHC2 antibodyAnti-REAM antibodyAnti-REC antibodyAnti-ZNF372 antibody |
Information sourced from Uniprot.org