| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission. Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process. |
| Protein Name | Palmitoyltransferase Zdhhc12Dhhc Domain-Containing Cysteine-Rich Protein 12Dhhc-12Zinc Finger Dhhc Domain-Containing Protein 12Zinc Finger Protein 400 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc12 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 12 antibodyAnti-Dhhc-12 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 12 antibodyAnti-Zinc Finger Protein 400 antibodyAnti-ZDHHC12 antibodyAnti-ZNF400 antibodyAnti-PSEC0008 antibody |
Information sourced from Uniprot.org
