Anti-ZDHHC12 antibody (83-133 aa) (STJ194319)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZDH12 at the amino acid range 83-133
General Information
| Short Description | Rabbit polyclonal anti-Palmitoyltransferase ZDHHC12 (83-133 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC12 |
| Gene ID | 84885 |
| Uniprot ID | ZDH12_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZDH12 at the amino acid range 83-133 |
| Immunogen Region | 83-133 aa |
| Specificity | This antibody detects endogenous levels of ZDH12 at Human/Mouse/Rat |
Additional Info
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission. Negatively regulates NLRP3-driven inflammation. Catalyzes NLRP3 palmitoylation, leading to its degradation via the chaperone-mediated autophagy (CMA) process. |
| Protein Name | Palmitoyltransferase Zdhhc12Dhhc Domain-Containing Cysteine-Rich Protein 12Dhhc-12Zinc Finger Dhhc Domain-Containing Protein 12Zinc Finger Protein 400 |
| Database Links | |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc12 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 12 antibodyAnti-Dhhc-12 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 12 antibodyAnti-Zinc Finger Protein 400 antibodyAnti-ZDHHC12 antibodyAnti-ZNF400 antibodyAnti-PSEC0008 antibody |
Information sourced from Uniprot.org