| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Palmitoyltransferase ZDHHC12 (83-133 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZDHHC12 |
| Gene ID: |
84885 |
| Uniprot ID: |
ZDH12_HUMAN |
| Immunogen Region: |
83-133 aa |
| Specificity: |
This antibody detects endogenous levels of ZDH12 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human ZDH12 at the amino acid range 83-133 |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission. Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process. |
| Protein Name | Palmitoyltransferase Zdhhc12Dhhc Domain-Containing Cysteine-Rich Protein 12Dhhc-12Zinc Finger Dhhc Domain-Containing Protein 12Zinc Finger Protein 400 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc12 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 12 antibodyAnti-Dhhc-12 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 12 antibodyAnti-Zinc Finger Protein 400 antibodyAnti-ZDHHC12 antibodyAnti-ZNF400 antibodyAnti-PSEC0008 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
