Anti-ZC3HAV1 antibody (211-260 aa) (STJ192605)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 211-260
General Information
| Short Description | Rabbit polyclonal anti-Zinc finger CCCH-type antiviral protein 1 (211-260 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZC3HAV1 |
| Gene ID | 56829 |
| Uniprot ID | ZCCHV_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 211-260 |
| Immunogen Region | 211-260 aa |
| Specificity | ZCCHV Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). |
| Protein Name | Zinc Finger Ccch-Type Antiviral Protein 1Adp-Ribosyltransferase Diphtheria Toxin-Like 13Artd13Inactive Poly Adp-Ribose Polymerase 13Parp13Zinc Finger Ccch Domain-Containing Protein 2Zinc Finger Antiviral ProteinZap |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusLocalizes In The Cytoplasm At Steady StateBut Shuttles Between Nucleus And Cytoplasm In A Xpo1-Dependent MannerIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Ccch-Type Antiviral Protein 1 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 13 antibodyAnti-Artd13 antibodyAnti-Inactive Poly Adp-Ribose Polymerase 13 antibodyAnti-Parp13 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 2 antibodyAnti-Zinc Finger Antiviral Protein antibodyAnti-Zap antibodyAnti-ZC3HAV1 antibodyAnti-ZC3HDC2 antibodyAnti-PRO1677 antibody |
Information sourced from Uniprot.org