| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 SUMO-protein ligase ZBED1 (329-379) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZBED1 |
| Gene ID: |
9189 |
| Uniprot ID: |
ZBED1_HUMAN |
| Immunogen Region: |
329-379 |
| Specificity: |
This antibody detects endogenous levels of human ZBED1 |
| Immunogen: |
Synthesized peptide derived from human ZBED1 AA range: 329-379 |
| Post Translational Modifications | Autosumoylated with SUMO1, SUMO2, and SUMO3. |
| Function | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCGCTGACTA-3' consensus sequences in gene promoters of ribosomal proteins. (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection. |
| Protein Name | E3 Sumo-Protein Ligase Zbed1Dna Replication-Related Element-Binding FactorPutative Ac-Like Transposable ElementZinc Finger Bed Domain-Containing Protein 1Dref Homolog |
| Database Links | Reactome: R-HSA-4551638 |
| Cellular Localisation | NucleusPml BodyIn Granular Structures(Microbial Infection) Upon Interaction With Human Adenovirus Early E1a ProteinThe Protein Is Redistributed To The Peripheral Areas Of Pml Bodies |
| Alternative Antibody Names | Anti-E3 Sumo-Protein Ligase Zbed1 antibodyAnti-Dna Replication-Related Element-Binding Factor antibodyAnti-Putative Ac-Like Transposable Element antibodyAnti-Zinc Finger Bed Domain-Containing Protein 1 antibodyAnti-Dref Homolog antibodyAnti-ZBED1 antibodyAnti-ALTE antibodyAnti-DREF antibodyAnti-hDREF antibodyAnti-KIAA0785 antibodyAnti-TRAMP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
