Anti-YES1 antibody (450-480) {Biotin} (STJ503565)

SKU:
STJ503565-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-YES1 (450-480) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: YES1
Gene ID: 7525
Uniprot ID: YES_HUMAN
Immunogen Region: 450-480
Immunogen: Synthetic peptide taken within amino acid region 450-480 on human YES1 protein. Host Rabbit Species Cross Reactivity Human, Monkey, Mouse, Rat
Tissue Specificity Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.
Post Translational Modifications Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. Palmitoylation at Cys-3 promotes membrane localization.
Function Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity.
Protein Name Tyrosine-Protein Kinase Yes
Proto-Oncogene C-Yes
P61-Yes
Database Links Reactome: R-HSA-1227986
Reactome: R-HSA-1433557
Reactome: R-HSA-1433559
Reactome: R-HSA-2029481
Reactome: R-HSA-210990
Reactome: R-HSA-2682334
Reactome: R-HSA-389356
Reactome: R-HSA-389513
Reactome: R-HSA-3928662
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Reactome: R-HSA-8940973
Reactome: R-HSA-912631
Reactome: R-HSA-9664323
Reactome: R-HSA-9664422
Reactome: R-HSA-9670439
Reactome: R-HSA-9680350
Cellular Localisation Cell Membrane
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cytosol
Newly Synthesized Protein Initially Accumulates In The Golgi Region And Traffics To The Plasma Membrane Through The Exocytic Pathway
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Yes antibody
Anti-Proto-Oncogene C-Yes antibody
Anti-P61-Yes antibody
Anti-YES1 antibody
Anti-YES antibody

Information sourced from Uniprot.org

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