| Function | Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ).additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell. |
| Protein Name | Yeats Domain-Containing Protein 4Glioma-Amplified Sequence 41Gas41Numa-Binding Protein 1Nubi-1Nubi1 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-8866907 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Yeats Domain-Containing Protein 4 antibodyAnti-Glioma-Amplified Sequence 41 antibodyAnti-Gas41 antibodyAnti-Numa-Binding Protein 1 antibodyAnti-Nubi-1 antibodyAnti-Nubi1 antibodyAnti-YEATS4 antibodyAnti-GAS41 antibody |
Information sourced from Uniprot.org
