| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-5 3 exoribonuclease 1 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | XRN1 |
| Gene ID: | 54464 |
| Uniprot ID: | XRN1_HUMAN |
| Specificity: | XRN1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). |
| Protein Name | 5'-3' Exoribonuclease 1Strand-Exchange Protein 1 Homolog |
| Database Links | Reactome: R-HSA-430039Reactome: R-HSA-450385Reactome: R-HSA-450513 |
| Cellular Localisation | CytoplasmDiscrete Foci At The Inner Surface Of The Cell Membrane |
| Alternative Antibody Names | Anti-5'-3' Exoribonuclease 1 antibodyAnti-Strand-Exchange Protein 1 Homolog antibodyAnti-XRN1 antibodyAnti-SEP1 antibody |
Information sourced from Uniprot.org