Anti-XIRP1-Ser295 antibody (STJA0003857)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser295 conjugated to KLH
General Information
| Short Description | Rabbit polyclonal anti-Xin Actin-binding Repeat-containing Protein 1-Ser295 for use in WB in Mouse, Canine, Human, Non-Human Primates and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Mouse/Canine/Human/Non-Human Primates/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Xirp1Uniprot ID=XIRP1_MOUSE" |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser295 conjugated to KLH |
Additional Info
| Tissue Specificity | Expressed at intercalated disks in cardiomyocytes of the heart (at protein level). Expressed in myocytes where it localizes to actin filaments prior to differentiation and is then expressed at nonstriated nascent myofibrils and Z-bodies during differentiation (at protein level). Expressed in highly differentiated myocytes at immature or mis-aligned Z-disks (at protein level). Expressed in skeletal muscle. |
| Function | Protects actin filaments from depolymerization. Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm. Required for development of normal skeletal muscle morphology and muscle fiber type composition. Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue. |
| Protein Name | Xin Actin-Binding Repeat-Containing Protein 1Cardiomyopathy-Associated Protein 1 |
| Cellular Localisation | Cell JunctionAdherens JunctionDesmosomeColocalizes With Actin Stress Fibers |
| Alternative Antibody Names | Anti-Xin Actin-Binding Repeat-Containing Protein 1 antibodyAnti-Cardiomyopathy-Associated Protein 1 antibodyAnti-Xirp1 antibodyAnti-Cmya1 antibodyAnti-Xin antibodyAnti-Xin-alpha antibody |
Information sourced from Uniprot.org