Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Wilms tumor protein (310-390 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | WT1 |
Gene ID: | 7490 |
Uniprot ID: | WT1_HUMAN |
Immunogen Region: | 310-390 aa |
Specificity: | WT1 Polyclonal Antibody detects endogenous levels of protein. |
Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 310-390 |
Function | Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. |
Protein Name | Wilms Tumor Protein Wt33 |
Database Links | Reactome: R-HSA-9690406 Reactome: R-HSA-9831926 |
Cellular Localisation | Nucleus Nucleolus Cytoplasm Isoforms Lacking The Kts Motif Have A Diffuse Nuclear Location Shuttles Between Nucleus And Cytoplasm Isoform 1: Nucleus Speckle Isoform 4: Nucleus Nucleoplasm |
Alternative Antibody Names | Anti-Wilms Tumor Protein antibody Anti-Wt33 antibody Anti-WT1 antibody |
Information sourced from Uniprot.org