| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WNT7B |
| Gene ID: | 7477 |
| Uniprot ID: | WNT7B_HUMAN |
| Immunogen Region: | 120-349 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human WNT7B (NP_478679.1). |
| Immunogen Sequence: | TAACSQGNLSNCGCDREKQG YYNQAEGWKWGGCSADVRYG IDFSRRFVDAREIKKNARRL MNLHNNEAGRKVLEDRMQLE CKCHGVSGSCTTKTCWTTLP KFREVGHLLKEKYNAAVQVE VVRASRLRQPTFLRIKQLRS YQKPMETDLVYIEKSPNYCE EDAATGSVGTQGRLCNRTSP GADGCDTMCCGRGYNTHQYT KVWQCNCKFHWCCFVKCNTC SERTEVFTCK |
| Tissue Specificity | Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate. |
| Post Translational Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. |
| Protein Name | Protein Wnt-7b |
| Database Links | Reactome: R-HSA-3238698Reactome: R-HSA-373080 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Protein Wnt-7b antibodyAnti-WNT7B antibody |
Information sourced from Uniprot.org