| Post Translational Modifications | Phosphorylated by PKA at Ser-15 in vitro, leading to activate kinase activity. Phosphorylation at Ser-15 by CaMK2, leading to increase its activity and promote metaphase II exit during egg activation. |
| Function | Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. |
| Protein Name | Wee1-Like Protein Kinase 2Wee1-Like Protein Kinase 1bWee1b KinaseMwee1b |
| Cellular Localisation | CytoplasmNucleusLocalizes Mainly In The NucleusExported From The Nucleus To The Cytoplasm Before Germinal Vesicle Breakdown (Gvbd)Allowing Meiosis Resumption |
| Alternative Antibody Names | Anti-Wee1-Like Protein Kinase 2 antibodyAnti-Wee1-Like Protein Kinase 1b antibodyAnti-Wee1b Kinase antibodyAnti-Mwee1b antibodyAnti-Wee2 antibodyAnti-Wee1b antibody |
Information sourced from Uniprot.org
