Anti-WDR54 antibody (99-149 aa) (STJ195002)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human WDR54 at the amino acid range 99-149
General Information
| Short Description | Rabbit polyclonal anti-WD repeat-containing protein 54 (99-149 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WDR54 |
| Gene ID | 84058 |
| Uniprot ID | WDR54_HUMAN |
| Immunogen | Synthesized peptide derived from the human WDR54 at the amino acid range 99-149 |
| Immunogen Region | 99-149 aa |
| Specificity | This antibody detects endogenous levels of WDR54 at Human/Mouse |
Additional Info
| Post Translational Modifications | Cross-linked to tightly form both dimers and trimers by TGM2. Cross-linking enhances the activation of EGF receptor-mediated signaling pathway. Cross-linking is inhibited by EGF. Ubiquitinated. EGF increases ubiquitination. |
| Function | Plays a role in the adhesion and fusion of the sperm-oocyte membrane through its interactions with IZUMO1 and IZUMO1R/JUNO. When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. |
| Protein Name | Wd Repeat-Containing Protein 54 |
| Database Links | |
| Cellular Localisation | VesicleCytoplasmCell MembraneAggregates In Vesicles When Cross-Linked |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 54 antibodyAnti-WDR54 antibody |
Information sourced from Uniprot.org