| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-WD repeat-containing protein 54 (99-149 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WDR54 |
| Gene ID: | 84058 |
| Uniprot ID: | WDR54_HUMAN |
| Immunogen Region: | 99-149 aa |
| Specificity: | This antibody detects endogenous levels of WDR54 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human WDR54 at the amino acid range 99-149 |
| Post Translational Modifications | Cross-linked to tightly form both dimers and trimers by TGM2. Cross-linking enhances the activation of EGF receptor-mediated signaling pathway. Cross-linking is inhibited by EGF. Ubiquitinated. EGF increases ubiquitination. |
| Function | When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. |
| Protein Name | Wd Repeat-Containing Protein 54 |
| Cellular Localisation | VesicleAggregates In Vesicles When Cross-Linked |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 54 antibodyAnti-WDR54 antibody |
Information sourced from Uniprot.org