| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. |
| Function | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway. |
| Protein Name | Wd Repeat Domain Phosphoinositide-Interacting Protein 3Wipi-3Wd Repeat-Containing Protein 45-LikeWdr45-Like ProteinWd Repeat-Containing Protein 45bWipi49-Like Protein |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | Preautophagosomal StructureLysosome |
| Alternative Antibody Names | Anti-Wd Repeat Domain Phosphoinositide-Interacting Protein 3 antibodyAnti-Wipi-3 antibodyAnti-Wd Repeat-Containing Protein 45-Like antibodyAnti-Wdr45-Like Protein antibodyAnti-Wd Repeat-Containing Protein 45b antibodyAnti-Wipi49-Like Protein antibodyAnti-WDR45B antibodyAnti-WDR45L antibodyAnti-WIPI3 antibody |
Information sourced from Uniprot.org
